Prion biology :a subject collection from Cold Spring Harbor perspectives in biology

Machine generated contents note: -- (preliminary) -- Preface -- Widening Spectrum of Prion Biology and Diseases -- Stanley B. Prusiner -- Experimental Approaches to Neurodegeneration -- Stanley B. Prusiner and Joel Watts -- The HET-S/s Prion Motif in the Control of Programmed Cell Death -- Roland Riek and Sven J. Saupe -- The Amyloid Phenomenon and its Links with Human Disease -- Christopher M. Dobson -- Protein Quality Control in Health and Disease -- Tatyana Dubnikov, Tziona Ben-Gedalya, and Ehud Cohen -- Yeast and Fungal Prions -- Reed B. Wickner -- Prions, Chaperones, and Proteostasis in Yeast -- Tatiana A. Chernova, Keith D. Wilkinson, and Yury O. Chernoff -- The 3D Structures of Amyloids -- Roland Riek -- Functional Prions in the Brain -- Joseph B. Rayman and Eric R. Kandel -- Prion-Like Polymerization in Immunity and Inflammation -- Xin Cai, Hui Xu, and Zhijian J. Chen -- Cross-ss Polymerization of Low Complexity Sequence Domains -- Masato Kato and Steven L. McKnight -- Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease? -- Danielly C.F. Costa, Guilherme A.P. de Oliveira, Elio A. Cino, Iaci N. Soares, Luciana P. Rangel, and Jerson L. Silva -- Molecular Genetics of Neurodegenerative Dementias -- Flora I. Hinz and Daniel H. Geschwind -- Tau PET Imaging -- Hartmuth C. Kolb and José Ignacio Andrés -- Potential Pathways of Abnormal Tau and a-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases -- Heiko Braak and Kelly Del Tredici -- Inactivation of Prions--Deep Brain Stimulation and Synuclein Prions -- Kurt Giles and Stanley B. Prusiner -- Index.

"Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology. Highlights include: - Experimental approaches to neurodegeneration - Prions, Chaperones, and Proteostasis in Yeast - The Aggregation and Prion-like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion-like Disease? - Neuropathology of NDs"--

"Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology"--